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244 Polymorphisms in these genes may lead to alterations in collagen synthesis, cross-linking, and fibril formation, resulting in weaker collagen fibers and an increased risk of ligament injuries

The same way that PD-1 has been combined with a plethora of approaches over the last decade

Treatment with rapamycin reversed these impairments by downregulating the phosphorylated AKT/mTOR pathway and upregulating BNIP3, AMBRA1, and Parkin expression