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For years, the biggest criticism of oral peptides was poor bioavailability-most were thought to break down in stomach acid before reaching circulation

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Two different strategies have been proposed to target these key aspects of the pathogenesis of autoimmunity [37] (Table 1)

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4 We then discuss the trafficking of metals to downstream metalloenzyme targets, contextualizing this discussion around the concept of a metallochaperone, focusing first on the biogenesis or maturation of metallocofactors in specific enzymes, followed by moving metals across a membrane