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The authors summarized their findings with the explanation that: Our study had insufficient power to detect a modest association between smoking only marijuana and increased risk of COPD

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As described, these changes are important because tobacco smoke above pH 6.0, as is generally observed in cigars, contains greater proportions of unprotonated nicotine, which affects puffing topography (the pattern of inhalation by a user) and increases oropharyngeal nicotine absorption (Henningfield et al., 1999

"The fact is, quitting smoking is hard," he says