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[ 449 ] BACH1 plays a beneficial role in MM as well

225 , 226 While uricosuric agents are generally well-tolerated, it is crucial to acknowledge that benzbromarone and probenecid may be associated with certain adverse effects

It is important that a beta-blocker is administered only after blockade of vascular alpha-adrenoceptors so that a hypertensive crisis does not occur because of unopposed alpha-adrenoceptor stimulation

There are reports of rare cases of toxicity following dosing within the therapeutic range, although there is debate about whether this latter category truly exists

Not suitable for pregnant or lactating women, or those with vitamin allergies

No peer-reviewed human trial data exists