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Six-well plate-adhered 4T1 and B16 cells were treated with culture media containing NSBSO and NCBSO of the same concentration (100 M) at 37 C for 10 h
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232 In a placebo-controlled trial in 46 patients with generalized anxiety disorder, the addition of L-theanine, at doses of 450900 mg per day, to antidepressant therapy for eight weeks improved sleep satisfaction and reduced severity of insomnia in those with mild sleep-related symptoms
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Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide