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Bones require robust blood supply to heal properly

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A: Active cancer, pregnancy/breastfeeding, active pancreatitis (for GLP-1s), family history of MTC (for GLP-1s), under 18 years old

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This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

They are widely involved in several key biological processes, such as cell cycle regulation, apoptosis induction, and immune responses