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Some compounding pharmacies adjust these concentrations based on prescriber preferences, but the 5/5/1 ratio represents the most common configuration available through major compounding pharmacies

Vitamin B12 deficiency can present with a range of physical and neurological symptoms

The variable R group gives rise to the four most commonly known cobalamins: cyanocobalamin (CNCbl), methylcobalamin (MeCbl), adenosylcobalamin (AdCbl, also known as cobamamide or 5-deoxyadenosylcobalamin), and hydroxocobalamin (OHCbl)

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The advisory committee's recommendation is not binding, but historically the FDA adopts PCAC vote outcomes in its final 503A bulk substance determinations