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J Histochem Cytochem 61(9):649658 Pyke C, Heller RS, Kirk RK, Orskov C, Reedtz-Runge S, Kaastrup P et al (2014) GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody

Therefore, the abnormality of glial cells may damage mitochondrial function, leading to the insufficient energy supply of DA neurons and eventually their death

long-term safety and efficacy in humans have not been fully established

Abbreviations AED: antiepileptic drug CNS: central nervous system CoA: coenzyme A CPS: carbamyl phosphate synthase GABA: -aminobutyric acid NAGA: N -acetyl glutamic acid NMDA: N -methyl-D-aspartate PCT: palmityl carnitine transferase VHE: VPA-induced hyperammonaemic encephalopathy VHT: VPA-induced hepatotoxicity VPA: valproic acid

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10.1136/rmdopen-2022-002600 9