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Such studies need to comprehensively integrate objective structural improvement indicators through quantitative MRI or arthroscopic evaluation and subjective clinical outcome measures such as pain and function scores, while focusing on treatment safety, local and systemic pharmacokinetics, and dynamic changes in preset biomarkers

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Lancet 389 (10088), 24922502

Pellets: Inserted under the skin and replaced every few months

Samples were incubated overnight at 4C, rinsed 5 in 1xPBS + 0.1% Triton X-100, then incubated overnight at 4C in secondary antibody + 10% NGS in 1xPBS + 0.1% Triton X-100

and 6) diclofenac (positive control): treated with 5 mg/kg diclofenac for 10 days (intra-muscularly)