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This approach has not lowered the rate of cardiometabolic disease

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doi: 10.1016/j.nmd.2015.03.001 189 LuJHolmgrenA

(2011) 6:e21107

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These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46