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Co-supplementation of aged rats with L-carnitine and -lipoic acid blunted age-related increases in reactive oxygen species (ROS), lipid peroxidation, protein carbonylation, and DNA strand breaks in a variety of tissues (heart, skeletal muscle, and brain) (21-30)

For example, Valine, leucine, and isoleucine biosynthesis and Alanine, aspartate, and glutamate metabolites were the second and third most enriched pathways (Fig

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Vitamin D may also exert a protective effect on the kidneys: studies in animal models suggest the active form of vitamin D may suppress kidney inflammation, fibrosis, and cell death