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1 Specifically, two non-cleavable linkers, three acid-cleavable linkers, eight enzyme-cleavable linkers, and three contain GSH-cleavable linkers appeared in the fourteen approved ADCs (the linkers in Mylotarg and Besponsa are both acid-cleavable and GSH-cleavable, Table 1)

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Maruyama H, Kato M, Mizuno O, Kataoka K, Matusi S: Transient thyrotoxicosis occurred after cessation of steroid therapy in a patient with autoimmune thyroiditis and rheumatoid arthritis

& Waxman, D

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There is no recovery from freeze damage at the molecular level