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The hierarchy of selenoprotein expression is more apparent when the intracellular level of selenium is limited 1

In DKD, continuous activation of RAAS leads to elevated pressure within the glomeruli, enhances the production of ROS, promotes tissue damage, triggers the release of proinflammatory cytokines, and stimulates the development of fibrosis in the glomeruli and tubulointerstitium

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Lyophilisation helps maintain peptide integrity over extended periods when stored under recommended conditions

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(Lond.) 42 , 618624 (2018)