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10.1007/s00204-012-0920-5 Arch

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A self-reinforcing cycle may develop Reduced mitochondrial efficiency may increase oxidative stress

Their further research showed (127) that GCK could inhibit the abnormal activation and differentiation of T cells in CIA and AIA animal models, and its potential molecular mechanism might be the inhibition of CCL21/CCR7-mediated DC migration and signal transduction between T cells and DC