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A third important factor to consider is its tolerability (i.e., how adverse its possible side effects can be)

DOI: 10.1097/MCC.0b013e32834cd339 Martin R et al (2020): -Adrenergic Receptors/Epac Signaling Increases the Size of the Readily Releasable Pool of Synaptic Vesicles Required for Parallel Fiber LTP

Implied but not really dwelled upon in the related A Certain Magical Index , when Mikoto drags Touma into pretending to be her boyfriend

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The research that has been done to date gives us some answers to these questions

Rockville, MD: US Department of Health and Human Services, National Cancer Institute