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Accumulated evidence has shown that misregulation in protein ubiquitination can lead to various human diseases, or defects in plant growth and disease defense

This property is why oral administration is discussed alongside injection in the literature, though human bioavailability data via the oral route has not been established

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Therefore, epigenetic biomarkers such as DNA methylation signatures and miRNA/lncRNA profiles are considered promising tools in the diagnosis of hypertension and the development of targeted therapies (Lee et al