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JCI Insight 4 (5)

The signaling pathway involving receptor activator of nuclear factor-B ligand (RANKL), its receptor (RANK), and osteoprotegerin (OPG) plays a pivotal role in the regulation of bone resorption

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This binding activated cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signaling pathway, resulting in the translocation of aquaporin-2 (AQP2) from the vesicle to the apical plasma membrane and markedly increasing the water reabsorption of principal cells (123)

The absence of standardised characterisation frameworks and clear regulatory pathways further complicate translational progress

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