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In the normal renal function group, one participant had a clinically significant vital sign abnormality (increased blood pressure) and one had a clinically significant ECG abnormality, with both reported as resolved mild TEAEs
This allows the body to consolidate gains and reduces any theoretical long-term risks from extended continuous use
Therefore, it has been observed that the antioxidant capacity found in the cellular matrix may become reduced in critical clinical conditions, including septic shock, cardiac bypass surgery, and reperfusion injury after organ transplantation, and renal dialysis [216]
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