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doi: 10.1007/s11427-019-9591-5

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A single intratympanic (IT) admininstration of SP-600125 (20 mg/ml) in P407 was given 24 hours prior to cisplatin intraperitoneal (IP) injection (12 mg/kg) in guinea pigs

Lactic acidosis portends a poor prognosis (by Kings College Hospital (KCH) criteria), and the mechanism of lactic acidemia is two-fold: NAPQI being present in excess and causing mitochondrial dysregulation, followed in subsequent hours by tissue hypoxia and decreased hepatic metabolism and clearance of lactate, leading to a two-hit effect on worsening of the lactic acidosis condition

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The key is just to separate them