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It is a two ATP-requiring enzymatically catalyzed process.[] After its synthesis, glutathione gets distributed in intracellular organelles, including endoplasmic reticulum (ER), nucleus, and mitochondria.[] NUCLEAR GLUTATHIONE In the nucleus, GSH prevents the oxidation of sulfhydryl groups of several proteins to disulfide groups

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

M., Fitzsimmons, C

J Thorac Dis 15:58235843

PLoS One 7:e45285

In addition, glutathione helps with the creation of cytokines, and it is necessary to maintain interferon-gamma production by dendritic cells, which is important towards protecting against intracellular pathogens including mycobacteria