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We do know that in the active site of peroxiredoxins, where the reaction of H 2 O 2 with a thiolate can occur up to six orders of magnitude faster than with glutathione in its thiolate form, the reaction can occur

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This scrambling, called disulfide exchange, produces misfolded peptides that do not function properly

Weathers S-PS, Zhu H, Knafl M, Damania A, Kamiya-Matsuoka C, Harrison RA, et al

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The bisbenzimide stain enabled counting live cell nuclei and dead apoptotic cells with condensed brightly labeled chromatin