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Pro-apoptotic signaling of JNK1 is mediated by the upstream MAP3K apoptosis signal-regulating kinase (ASK1) cascade (147)

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Side effects and safety profile Across the combined Phase 3 Tesamorelin database of over 800 treated subjects, the most frequently reported adverse events were injection site reactions (erythema, pruritus, small local hematoma) at roughly 25 percent of subjects, arthralgia and myalgia at 10 to 15 percent, and peripheral edema at 6 to 8 percent