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Rebound hunger occurs with appetite-suppressing medications when the brains hunger-regulating neurons, which have been pharmacologically suppressed, suddenly regain activity upon drug cessation

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In a phase 2 study in people with obesity (without T2D), retatrutide (doses 1 to 12 mg) has led to a dose-dependent WL up to 24.2% at the end of the 48-week treatment period compared to 2.1% with placebo [81]