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Individual academic studies cannot serve as the primary evidence for drug approval

doi:10.1056/NEJMoa2502081 Enebo LB, Berthelsen KK, Kankam M, et al

PLS patients experience nearly complete DPP1 function loss accompanied by dramatically reduced NSP activity, clinically manifesting primarily as palmoplantar hyperkeratosis and severe periodontitis

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At that point, most doctors recommend taking a six-to-nine month break to give your melanocytes a chance to stabilize before continuing treatment