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The MTHFR C677T polymorphism is common, affecting around 24% of the population overall, although prevalence varies considerably between ethnic groups

By performing gene set enrichment analysis (GSEA) limited to human-derived reads, we confirmed the upregulation of senescence and IFN- response signatures on palbociclib treatment and their downregulation when compared with palbociclib + RSL3-treated mice (Fig