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Each of the three major risk factors poses approximately the same increase in risk of CHD for the person with the risk factor, but cigarette smoking is far more prevalent as a risk factor for CHD in the American population than either hypertension or elevated serum cholesterol

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Nicotine dependence can be its own long-term problem

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[156] found that CSE enhanced both mRNA and protein expression of IL-8, which was important for neutrophil chemotaxis, accompanying with phosphorylation of p38 MAPK and MEK2 in human pulmonary cells