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Fallah H, Hon M, Rademaker M, Haady Fallah C (2021) Isotretinoin in the management of acne vulgaris: practical prescribing

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The difference is delivery

Generally, HO-1 levels remain low across diverse tissues except for the spleen, but diverse stimuli (like hydrogen peroxide, UV radiation, endotoxins, and hypoxia) can cause a strong inducible response for shielding cells from damaging oxidative and inflammatory agents [34]