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Mendelian randomization evidence indicates that elevated KYN levels have a causal relationship with increased risk of depression, with each standard deviation increase in KYN corresponding to ~ 1.4-fold higher odds of developing depression [50]

Rakowska A, Slowinska M, Kowalska-Oledzka E, Olszewska M, Czuwara J, Rudnicka L (2009) Alopecia areata incognita: true or false

So the naturally occurring peptide goes and does a bunch of things, those pleiotropic effects

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