Regarding the mechanism of PBMs action on chondrocytes, studies confirm that PBM upregulates the gene and protein expression of type II collagen and aggregated proteoglycans, significantly promoting chondrocyte proliferation and activity ( in vitro experiments reveal that PBM, through close-range efficient irradiation, simultaneously activates the Sox9-centred ECM synthesis pathway while suppressing the inflammation-catabolism pathway mediated by NF-B and others
Additionally, ex vivo exposure of amniotic fibroblasts to cortisol, endotoxin, or both led to increased 11-HSD1 expression (300)
doi: 10.18632/aging.102831 121 LeiZNTengQXTianQChenWXieYWuKet al
Medical and Editorial Standards Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims
10.1016/j.jhazmat.2024.134054 J
The first thing I noticed is just how thin the formula is