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Further consideration for collecting data in this population is needed

Probably due to the binding preference of APAP to the active site of each P450 isomer, it is oxidized via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Chen et al., 1998)

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Glutathione does not meaningfully induce or inhibit CYP enzymes at physiological or supplemental doses

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