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Its not only about effectivenesscomfort matters too

It has roots in traditional hacker culture but applies to technology that modifies something organic, from altering cells in a petri dish to ultra-freaky grinder body tweaks, like implanting speakers in your eardrums or embedding a vibrator near a mans pelvis (this exists and is called the Lovetron 9000), or, very recently, editing your own genes

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The FASEB Journal 4 (5): 14501459

By appreciating the potential adverse effects of pharmacological agents on the gut microbiota, researchers and clinicians can develop more effective, tailored therapies that prioritize not only the alleviation of ME/CFS symptoms but also the maintenance of gut health [6, 7, 10, 11]