Int J Med Mushrooms 7(1&2):111118 Zhu LN, Tang Q, Zhou S, Liu Y, Zhang Z, Gao X, Wang S, Wang Z (2014a) Isolation and puri f ication of a polysaccharide from the caterpillar medicinal mushroom Cordyceps militaris (ascomycetes) fruit bodies and its immunomodulation of RAW 264.7 macrophages
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doi: 10.1007/s12325-010-0059-9 121 RheeC
Inhibition of GCH1 reduced BH4 and resulted in enhanced erastin-induced iron accumulation and lipid peroxidation, thereby enhancing ferroptosis sensitivity, while BH4 supplementation suppressed ferroptosis-related changes caused by GCH1 downregulation
Similarly, earlier studies led by Sikiric and colleagues in the 1990s suggested safety and benefit in gastrointestinal conditions such as ulcerative colitis, but these reports were published only in abstracts or local conference proceedings, with no independent replication or peer-reviewed validation
Gilhus NE, Tzartos S, Evoli A, Palace J, Burns TM, Verschuuren J