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Robust improvement in glycaemic control (HbA1c) in people with type 2 diabetes, with dose-dependent reductions observed in clinical trials

Subsequent work by Pickart and Margolina identified clusters of affected genes spanning DNA repair, antioxidant defense, ubiquitinproteasome activity, anti-inflammatory signaling, and tissue remodeling [2]

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doi: 10.1146/annurev-pharmtox-011112-140320 63

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