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12,26 Furthermore, the formation of NAPQI adducts contributes to oxidative stress, mitochondrial dysfunction, disrupted Ca 2+ homeostasis, necrotic cell death, centrilobular necrosis, and eventual liver failure (Figs

Fourthly, the severity of the IVD degeneration possibly influences the therapeutic effect of injected cells and/or growth factors, since degenerated CLCs may have lost their chondrogenic potential and the effect of injected cells and/or growth factors may differ between early and severely degenerated IVDs [90]

Namely, the non-nucleoside reverse-transcriptase inhibitor, Efavirenz, was found to inhibit Complex I in primary rat neuron cultures (Blas-Garca et al