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[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Sekhar R.V

In addition, we analysed several circulatory intermediates of the methylation cycle (including the methioninehomocysteine, folate, and transsulfuration pathways), which are linked to the methylation of catechol estrogens by COMT

Based on the available research, I believe conservative dosing produces the best outcomes for most people