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During electron transfer through the respiratory chain, mitochondria generate large portions of ROS, such as superoxide, hydroxyl radical, hydroperoxyl radical, and hydrogen peroxide (H 2 O 2 ), into the matrix and the intermembrane space

These include allergic reactions, which can be very serious

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Kidney conditions may reduce the kidneys ability to filter and clear vitamin B12 and its binding proteins, also leading to higher measured levels