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As a nuclear transcription factor induced by hypoxia, HIF-1 may be involved in mediating hypoxia in vital organ tissues during the pathological process of depression [125]

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For example, SOD, the only antioxidant enzyme that eliminates superoxide anions in mammals, has analogs that effectively inhibit redox damage to biological macromolecules

ACS Nano 15 , 67096722 (2021)