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The primary safety outcome was the occurrence of any serious adverse events

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doi: 10.1016/j.resmic.2010.09.017, 81 Olsson-FrancisK.de la TorreR.CockellC

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Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity

(31) showed that neurons in the brains of patients with T2DM secrete the regulatory factor angiopoietin-like protein 8 (ANGPTL8) into the hippocampus, which activates microglia to up-regulate pro-inflammatory factors and axonal damage, leading to cognitive impairment