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Adaptive regulation strategies for ROS homeostasis The adaptive regulation of ROS balance is a complex and intricate process involving a variety of biological mechanisms and signaling pathways

Oral supplements (adjacent option): Oral glutathione or liposomal forms, plus glutathione precursors (like NAC)

Sequences of qPCR primers can be found in Supplementary Table 1

In turn, the oxidized vitamin C, thanks also to GSH, can revert to its reduced form (7)

MOTS-c is a short peptide (16 amino acids), which makes it relatively resistant to the enzymatic degradation that degrades larger peptides, but also means that reconstitution technique and storage conditions matter considerably

Different cell types have varying sensitivities to the duration and concentration of H 2 O 2 treatment [84], which may be related to specific signaling pathways and antioxidant defense mechanisms within the cells [85]