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The Phase I trial of the novel HDAC inhibitor Bisthianostat (BIS, oral tablets, starting dose of 100 mg, escalated to 200/400 mg, administered twice weekly) demonstrated good safety as a monotherapy, with no Grade 3/4 non-hematologic toxicities

This is a critical distinction

10.3748/wjg.v23.i48.8465 [DOI] [PMC free article] [PubMed] [Google Scholar] FarokhiSisakht, F

Those who did not receive enough were associated with a much higher risk for obesity

Systemic physical examination was normal

952 Between 2010 and 2022, Medicaid spending on home and communitybased services increased from 48% to 65% of total longterm services and supports expenditures