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In a study of 124 patients admitted for acute myocardial infarction [87] who reported marijuana use and controlled for other triggers, there was a 4.8-fold increase in the risk of myocardial infarction (95% confidence interval [CI] 2.49.5, p = 0.001) in the first hour following marijuana use as compared with periods of non-use

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The company has submitted a $47bn (38bn) offer to buy the 58 per cent of US rival Reynolds it does not already own, says the Financial Times