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GI dysfunction, a common comorbidity in PD, further contributes to fluctuations in levodopa absorption and plasma concentrations, thereby triggering or exacerbating the on-off phenomenon [86, 87]

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There is no controlled human trial showing that Epithalon extends lifespan, prevents age-related disease or produces a clinically meaningful reduction in biological age

Most users do not experience significant side effects from taking glutathione supplements

Therefore, the changes in the dosage form or the combination with other drugs can further compensate for the weakness of low bioavailability of berberine