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The substrate specificity becomes dramatically restricted in mammalian tyrosinase which uses only L-form of tyrosine or DOPA as substrates, and has restricted requirement for L-DOPA as cofactor

doi: 10.1038/ni.1818 18 AlikhanMAHuynhMKitchingAROoiJD

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Symptom limitation was defined as apparent unconsciousness, a form of central nervous system (CNS) dysfunction that resembles what is observed in ~80% of human heat stroke victims 52