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ROXY9 is oxidized to ROXY9-S 2 depending on the redox potential of the GSH/GSSG couple, while class I GRXs adopt a stable equilibrium between the glutathionylated and the S 2 -containing state over a wide range of redox potentials established by GSH/GSSG

In contrast, the other three cell lines displayed relatively higher GSH:GSSG ratios, suggesting more effective antioxidant buffering 48

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