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Across those trials, AOD-9604 demonstrated a strong safety profile adverse events were comparable to placebo, no genotoxicity was found, and it showed no negative effect on glucose or insulin sensitivity

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Endocrinology , 142(12), 51825189

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IGF-1 and growth hormone receptor activation controls confirming that AOD-9604 does not engage the classical hGH receptor or elevate IGF-1, distinguishing its mechanism from full-length growth hormone in cell-based reporter systems

This deficiency can lead to megaloblastic anemia, where the body produces large, abnormal red blood cells that cannot function effectively, resulting in symptoms such as fatigue, weakness, and neurological issues