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Notably, the rise in diabetes-induced cognitive dysfunction has garnered widespread attention

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These results, which suggest that D-Nle- Tyr-Ile-NH-(CH 2 )5-CONH 2 is likely to be relatively hydrophobic, are in agreement with the outcome of QSAR modeling estimates generated by ADMET Predictor that calculated an octano water partition coefficient of 28.18 for D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 (Table 6)

Paramagnetic relaxation enhancement (PRE) experiments were performed using a Bruker 600 MHz NMR spectrometer with a cryogenic probe (GIST, Gwangju)

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