Pediatr Allergy Immunol 17:291296 Rossignol DA, Frye RE (2014) Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism
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doi: 10.1089/pop.2015.0003 20
As members of the dioxygenase family, they are cytosine demethylases in DNA, RNA, and histones, such as the ten-eleven translocation enzyme (TET) dioxygenase family, DNA and RNA demethylases of the AlkB homolog (ALKBH) family and Jumonji C domain-containing histone demethylases (JHDMs) ( 2+ state in the catalytic cycle of TET, thus increasing the oxidation rate of 5mC up to 8-fold in a dose- and time-dependent manner (Yin et al., 2013
Using unregulated clinics also adds risks of infection and impure substances
