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It is notable for its remarkable stability compared to many other endogenous peptides

H 2 O 2 and lipid peroxides) while the latter conjugates GSH with toxic metabolites for their efflux through transporters

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doi: 10.1104/pp.16.00648 127 RouhierN.JacquotJ

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TAT-M2PBM, a peptide that disrupts TRPM2-protein kinase C (PKC), a cell-permeable peptide that disrupts TRPM2-PKC coupling, significantly inhibits eNMDARs-mediated excitotoxicity and produces potent protection against ischemic stroke in vitro and in vivo [79]