Download figure Open in new tab Download powerpoint Figure 5 Various intracellular processes further promote chemotherapy resistance and are refractory to other anticancer modalities
As confirmation, we used the crisis that occurred with the high intra-abdominal pressure-induced syndrome, in which intra-abdominal hypertension simultaneously affected all abdominal vessels and organs for a considerable period and restrained the ability to recruit alternative pathways, such that a deadly situation was created before therapy initiation
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Peroxiredoxins seem to be important in antioxidant metabolism
Gutbloodbrain axis disruption: Dysbiosis affects communication along the gutbrain axis, increasing intestinal permeability (leaky gut) and allowing microbial toxins like LPS and bacterial amyloids to translocate into systemic circulation, triggering systemic inflammation (Wu et al., 2021)
This synergy is important because it means boosting either peptide might partially compensate for deficiency in the other