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It is not clear what doses were used and the period of use associated with the risk of liver damage

Science 290(5493):985989 Giorgi FS, Bandettini di Poggio, A, Battaglia G, Pellegrini A, Murri L, Ruggieri S, Paparelli A and Fornai F (2006) A short overview on the role of alpha-synuclein and proteasome in experimental models of Parkinsons disease

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4 Effects of overapplication of lime on soil biota While liming has several benefits to survival and functioning of soil biota, overapplication of lime leads to soil alkalinity which can be as detrimental to soil biota as acidity [389]